Streamline and customize high resolution accurate mass data analysis with Thermo Scientific™ Compound Discoverer™ small molecule identification software. Compound Discoverer empowers researchers to strategically collect, organize, store, and analyze data for both targeted and untargeted workflows.

Lipidomics is crucial to understanding cellular physiology and pathology, and lipid profiling for disease phenotype analysis is a rapidly growing area in translational medical research.

Deep Protein Characterization Is Crucial Pharmaceuticals have historically been small molecules.Today however, many newly approved drugs are derived from proteins. For protein therapeutics to be effective, they must be produced in biologically active forms, which require proper folding, and post-translation modifications (PTMs). Detailed characterization of these modifications is crucial. A comprehensive verification of the protein's (amino acid) sequence, assessment of purity and identification of impurities in a recombinant protein drug product along with a detailed characterization of the existing PTMs, is a regulatory requirement prior to its approval for clinical use.

Even after preliminary identification and validation, scientists face the critical, time-consuming task of interpreting their proteomics data - extracting meaningful biological information from multiple, complex data sets. Thermo Scientific™ ProteinCenter software is a web-based data interpretation tool that enables scientists.

ProteinCenter software is illustrated in the following workflows.

• TGO annotation analysis
• Pathway based protein selection
• Biological interpretation of proteins

Thermo Scientific™ ProSightPC software, the first stand-alone software for analyzing top-down proteomics data, has been enhanced to add support for middle-down and bottom-up experiments, making it an all-around tool for identification and characterization of both intact proteins and peptides.

ProSightPC software is illustrated in the following workflows..

• Top Down protein MS/MS ID
• Elucidation of unknown PTMs
• Protein database curation

Deep data mining by combining multiple search engines and information from multiple dissociation techniques. Utilize advanced tools for database search results validation and statistically rigorous estimation of false discovery rates. Percolator for maximizing the number of true positive Peptide Spectrum matches. Thermo Scientific™ Proteome Discoverer™ software is illustrated in the following workflows. Iterative search strategies Multi-search engine comparison iTRAQ/TMT quantification